Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet KD is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy HBO 2 T saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia. Since these non-toxic therapies exploit overlapping metabolic deficiencies of cancer, we tested their combined effects on cancer progression in a natural model of metastatic disease. We used the firefly luciferase-tagged VM-M3 mouse model of metastatic cancer to compare tumor progression and survival in mice fed standard or KD ad libitum with or without HBO 2 T 2. Tumor growth was monitored by in vivo bioluminescent imaging.
Not just smaller than cancer cells, but even smaller than healthy cells that feed on glucose. DER has been shown to have anti-tumor effects in a variety of cancers, including brain, prostate, mammary, pancreas, lung, gastric, and colon , , , , , , , , , . Hyperbaric Oxygen : Click here. The atmosphere in it consists practically of pure oxygen under high pressure, and the patient stays there for some time. This finding strongly supports the efficacy of the KD and HBO 2 T as therapies to inhibit tumor progression and prolong survival in animals with metastatic cancer. Market Place. Fomchenko E, Holland E Mouse models of brain tumors and their applications in preclinical trials. Thus, the cellular response to tumor hypoxia is mediated by several of the same pathways that are overly active in cancer cells with mitochondrial damage and high rates of aerobic glycolysis. Its amount is difficult to regulate through a diet since the body produces it in sufficient quantities by itself, but with a calorie-restricted diet, its activity is still reduced. Both of them trigger ketosis and radically reduce the amount of glucose in the blood — the leading food for cancer. Tail vein injection models of metastatic cancer eliminate the important steps of local tissue invasion and intravasation into the vasculature, again failing to represent the true disease phenotype. Theoretically, it can even replace traditional cancer treatments, as it is not as toxic as chemotherapy.
Tumor bioluminescence in mice. Nutrition and cancer 60 : 61— Perhaps the most important limiting factor in the development of new treatments for metastatic cancer is the lack of animal models that accurately reflect the true nature of metastatic disease. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Published online Jun 5. In other words, oxygen powers the healing process. The ketogenic diet KD is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Additionally, radiation and many chemotherapy drugs work by producing free radicals within the tumors, leading to cell death. This feature, known as The Warburg Effect, is linked to mitochondrial dysfunction and genetic mutations within the cancer cell , , . In an animal model of cancer cachexia, administration of a low carbohydrate, high fat diet prevented weight loss of the animals while simultaneously decreasing tumor size .